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KMID : 1100220050040010014
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Dementia and Neurocognitive Disorders
2005 Volume.4 No. 1 p.14 ~ p.19
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Genetic Aspects of Frontotemporal Dementia
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Kim Yun-Joong
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Abstract
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Frontotemporal lobar degeneration (or frontotemporal dementia, FTD) is a group of disorders which is clinically, neuropathologically and genetically heterogeneous. Discovery of tau mutation in “frontotemporal dementia and parkinsonism linked to chromosome 17” (FTDP-17) led to a big progress in our understanding of frontotemporal dementia and tauopathies. However, substantial number of sporadic and familial FTD are not associated with tau pathology. Tau mutations have been found only in a part of familial FTD, and a number of new loci linked to familial FTD have been identified. This review will cover evolving knowledge and concept of FTD with respect to genetic and neuropathological heterogeneity.
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KEYWORD
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Frontotemporal dementia, MAPT, Mutation, Haplotype, Mutation, Familial dementia
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